ACE (Angiotensin converting enzyme) inhibitors

What do they do?

Angiotensin converting enzyme (ACE) inhibitors block the effects of angiotensin II, a hormone produced by your kidneys. Thereby, ACE inhibitors cause your blood vessels to relax and this lowers your blood pressure. Accordingly, the work load of your  heart is reduced.

What are the expected benefits?

ACE inhibitors reduce heart failure-related hospitalisations, prolong life, and improve exercise tolerance and quality of life.

Side effects

  • Since ACE inhibitors may affect your blood pressure, it should be monitoring by yourself regularly.
  • Your potassium level might increase and your kidney function might be affected. Therefore your doctor will confirm that it is still within a safe range by ordering blood tests.
  • Some people develop a dry cough with ACE inhibitors. If this happens to you, your doctor can lower the dose or switch you to another medication.
  • Less commonly, people may experience changes in taste.
  • Rarely, people taking ACE inhibitors develop skin rashes.
  • Very rarely swelling of lips or throat may occur. This is an alarming symptom! You should get medical help immediately if this happens!

Tip

Your doctor may advise you to take the first dose of your ACE inhibitor before going to bed to try and prevent dizziness. In case you feel dizzy in the morning, try moving your feet back and forth about ten times before you stand up. Or, you may find it helpful to dangle your legs over the side of the bed before sitting up, and then sit at the side of the bed for a minute before standing. Avoid standing up too quickly, either from sitting or bending down, as this can make you feel dizzy. Take your time and allow your body to adjust!

ACE inhibitors used in heart failure

The international treatment guidelines favour certain ACE inhibitors.

Their names are, in alphabetical order:

  • Captopril
  • Enalapril
  • Lisinopril
  • Ramipril
  • Trandolapril

 

Animation

Animation explaining how ACE inhibitors work in heart failure

Return to Heart failure medicines

 

ESC Guidelines for Heart Failure

What patients need to know

This guide for patients from the European Society of Cardiology aims to provide an overview of the latest evidence-based recommendations for the diagnosis and treatment of heart failure.

In particular, it should help patients to understand the:

  • main types of heart failure
  • medicines used to treat heart failure
  • devices that may be appropriate
  • importance of rehabilitation
  • management by a multidisciplinary team
  • importance of self-care in managing your own condition

Learn more

AN ANIMATED JOURNEY THROUGH HEART FAILURE

A series of 9 simple, captivating animations explaining heart failure and its treatment.

These narrated animations explain how a healthy heart works, what happens to it in heart failure and how various treatments work to improve your health.

PATIENT AND CAREGIVERS VIDEOS

In this section you can watch, listen or read interviews with other people with heart failure and their caregivers.

VISIT OUR FACEBOOK PAGE

and share your own views and experiences with other patients, families and caregivers.

heartfailurematters.org is a European Society of Cardiology website

The heartfailurematters.org website was developed under the direction of the Heart Failure Association of the European Society of Cardiology (ESC). The ESC is a world leader in the discovery and dissemination of best practices in cardiovascular medicine. Our members and decision-makers are healthcare professionals who volunteer their time and expertise to represent professionals in the field of cardiology in Europe and beyond.

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